PHYSICAL EXERCISE AND FITNESS : MEDICAL CONDITIONS OBESITY : MEDICAL GENETICS : MEDICAL RESEARCH: Physical Activity Helps to Counteract Weight Gain from Obesity-Causing Gene Variant

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PHYSICAL EXERCISE AND FITNESS : MEDICAL CONDITIONS OBESITY : MEDICAL GENETICS : MEDICAL RESEARCH: Physical Activity Helps to Counteract Weight Gain from Obesity-Causing Gene Variant

David P. Dillard
Administrator



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PHYSICAL EXERCISE AND FITNESS :

MEDICAL CONDITIONS OBESITY :

MEDICAL GENETICS :

MEDICAL RESEARCH:

Physical Activity Helps to Counteract Weight Gain
from Obesity-Causing Gene Variant

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Physical Activity Helps to Counteract Weight Gain
from Obesity-Causing Gene Variant

Study used meta-analyses that account for physical activity
and identified 11 novel obesity variants

Date: April 27, 2017

Source: PLOS

Science Daily

Science News

https://www.sciencedaily.com/releases/2017/04/170427141743.htm

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Summary:

Physical activity can reduce the weight-gaining effects of the
genetic variant that carries the greatest risk of obesity, report.

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Physical activity can reduce the weight-gaining effects of the genetic
variant that carries the greatest risk of obesity, report Mariaelisa Graff
of the University of North Carolina at Chapel Hill, Tuomas Kilpelnen of
University of Copenhagen and colleagues April 27th, 2017 in PLOS Genetics.

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With people consuming more calories and being less physically active, the
world has witnessed an obesity epidemic, but not everyone is gaining
weight. Previous studies suggest that a person's susceptibility to
becoming obese can be reduced by physical activity. To see how physical
activity and genetic variants related to obesity interact to affect weight
gain, Graff and colleagues performed genome-wide interaction meta-analyses
using more than 200,000 individuals. They categorized individuals as
active or inactive, screened them for about 2.5 million genetic variants
and correlated that data with physical indicators of obesity, including
body mass index, waist circumference and waist-to-hip ratio. The study
finds that physical activity can reduce the weight-gaining effects of the
strongest known genetic risk factor for obesity, the FTO gene, by about
30%. Accounting for physical activity also enabled the researchers to
identify 11 novel genetic variants linked to obesity, suggesting that
physical activity and other relevant environmental factors should be
considered when looking for novel genes.

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The meta-analyses confirm previous findings that physical activity reduces
the effect of the FTO gene, but the underlying cause of this interaction
is still unknown.


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The complete article may be read at the URL above.

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