MEDICAL: PHARMACY PHARMACEUTICAL PHARMACOLOGY: DRUG: ADVERSE EVENT: Diprivan Risk Well-Known to Doctors

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MEDICAL: PHARMACY PHARMACEUTICAL PHARMACOLOGY: DRUG: ADVERSE EVENT: Diprivan Risk Well-Known to Doctors

David P. Dillard
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MEDICAL: PHARMACY PHARMACEUTICAL PHARMACOLOGY: DRUG: ADVERSE EVENT:
Diprivan Risk Well-Known to Doctors



Diprivan Risk Well-Known to Doctors
updated 9:08 p.m. EDT, Fri July 3, 2009
CNN Entertainment
<http://www.cnn.com/2009/SHOWBIZ/Music/07/03/jackson.diprivan/>



LOS ANGELES, California (CNN) -- While authorities do not yet know what
killed Michael Jackson, the possibility that anesthetics -- particularly
the drug Diprivan -- might be involved continues to swell with each new
revelation.

On Friday, The Associated Press quoted an unnamed law enforcement source
saying investigators found Diprivan in Jackson's Holmby Hills home.

A nutritionist, Cherilyn Lee, said earlier in the week that Jackson
pleaded for the drug despite being told of its harmful effects.

Sources close to Jackson told CNN's Dr. Sanjay Gupta that the singer, who
suffered from a sleep disorder, traveled with an anesthesiologist who
would "take him down" at night and "bring him back up" during a world tour
in the mid-90s.

The California State Attorney General's office has now said it is helping
the Los Angeles Police Department in Jackson's death investigation. The
U.S. Drug Enforcement Administration is also looking into the role of
drugs, two federal law enforcement sources said.

The drug Diprivan, known by its generic name Propofol, is administered
intravenously in operating rooms as a general anesthetic, the manufacturer
AstraZeneca said Friday.

"It is neither indicated nor approved for use as a sleep aid," said
spokesman Tony Jewell.

The drug works as a depressant on one's central nervous system.

"It works on your brain," said Dr. Zeev Kain, the chair of the
anesthesiology department at the University of California Irvine. "It
basically puts the entire brain to sleep."

However, once the infusion is stopped, the patient wakes up almost
immediately.

"So if you're going to do this, you'd have to have somebody right there
giving you the medication and monitoring you continuously," Kain said.



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